Fibroblast growth factor 23 and heart failure: the plot thickens
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چکیده
منابع مشابه
Fibroblast Growth Factor-23 Fans the Flames of Heart and Kidney Failure.
SEE PAGE 829 C hronic kidney disease (CKD) promotes cardiac injury, and heart failure begets kidney injury. Although shared risk factors such as diabetes, hypertension, and atherosclerosis are wellknown igniters of the combustible interaction between chronic heart and kidney diseases, identification of the accelerants that drive the full-fledged public health conflagration of “cardiorenal” dise...
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متن کاملThe plot thickens.
The dilator function of the vascular endothelium is critical for optimal tissue perfusion, and this is brought into stark reality in a number of diseases, such as hypertension, diabetes, and preeclampsia, in which endothelium-dependent vasodilator function is impaired. Prostacyclin and nitric oxide (NO) were the earliest identified endothelium-dependent vasodilators, but it was soon found that ...
متن کاملFibroblast Growth Factor‐23 and Incident Coronary Heart Disease, Heart Failure, and Cardiovascular Mortality: The Atherosclerosis Risk In Communities Study
BACKGROUND Fibroblast growth factor-23 (FGF-23) is a hormone involved in phosphorous regulation and vitamin D metabolism that may be associated with cardiovascular risk, and it is a potential target for intervention. We tested whether elevated FGF-23 is associated with incident coronary heart disease, heart failure, and cardiovascular mortality, even at normal kidney function. METHODS AND RES...
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Fibroblast growth factor-23 (FGF-23) is a phosphate regulatory 251-aminoacid hormone secreted by osteocytes and acts as regulator phosphorus reabsorption in the proximal tubule of nephron and 1,25-dihydroxyvitamin D synthesis. Recent clinical studies have shown that higher serum FGF-23 levels are associated with subclinical cardiovascular (CV) disease, with new Heart Failure (HF) and chronic ki...
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ژورنال
عنوان ژورنال: Nephrology Dialysis Transplantation
سال: 2015
ISSN: 0931-0509,1460-2385
DOI: 10.1093/ndt/gfv401